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Objective To investigate drug adverse reactions caused by Qingkailing injection,in order to provide a reference for clinical drug rational use.Method 2003-2008 Qingkailing Injection Case reports of adverse reactions collected from the Guizhou Province Monitoring Center Database was analysed descriptively.Result The occurrence of Qingkailing injection adverse reactions was not correlated to gender.The clinical manifestation was mainly for allergic reactions(305 cases,accounting for 35.59%)and systemic damage(417 cases,accounting for 48.66%).There were 652 cases adverse reactions occurred in 30min accounting for 76.08%.Conclusion Clinical physicians,pharmacists should attach importance to Qingkailing injection adverse reactions,persist in rational drug use and focus on the observation,after druguse.
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0.05).Conclusion Under atherosclerosis conditions,CO_2 pneumoperitoneum has an adverse influence on the blood flow of the common carotid arteries which may be associated with increased intra-bdominal pressure,absorbed CO_2 gas.
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Objective To investigate the influence of CO_2 pneumoperitoneum on intestinal mucosa permeability in rats with liver cirrhosis.Methods Fifty rats were randomly divided into following groups: control group(n=5),cirrhosis group(n=5) and pneumoperitoneum group(n=40);the pneumoperitoneum group was further divided into 8 mm Hg group(n=20) and 13 mm Hg group(n=20).Four time points were chosen,including 0.5,2,6,and 12 hours after the end of pneumoperitoneum.After rat models with cirrhosis were established successfully,the abdominal cavity was insufflated with CO_2 and maintained under the pressures of 8 mm Hg and 13 mm Hg respectively for two hours.The portal venous blood was collected and the levels of D-lactic acid and endotoxin were measured.Results The levels of endotoxin and D-lactic acid in cirrhosis group were much higher than those of control group(P0.05).Conclusion The intestinal mucosa permeability is increased in rats with liver cirrhosis.It can be further increased under CO_2 pneumoperitoneum with certain pressure and time and in a pressure-dependent manner.The permeability can decrease after removal of pneumoperitoneum.
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Objective To study the clinicopathological features and treatment modality of patients with gastric remnant cancer after distal gastrectomy. Methods The data of 25 patients with gastric remnant cancer undergoing surgery during the recent 9 years were analyzed retrospectively.Results Patients with gastric remnant cancer showed a greater male predominance(5∶1). The mean interval between previous gastrectomy and diagnosis of gastric remnant cancer was 24.5 years,ranging from 12 to 35 years.The primary operation was Billroth Ⅱ reconstruction in 80% of the cases. R0 resection for gastric remnant cancer was performed in 14 cases,Palliative resection in 11 cases,and adjuvant chemotherapy in 18 cases. The 1-,3-and 5-year overall survival rate was 72.0%,56.0% and 36.0%,respectively,while the respective survival rate was 78.5%,71.4%,and 50.0% in radical surgery group,and 63.6%,36.3% and 18.1% in palliative surgery group(P
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Objective To evaluate the significance of HCV-RNA testing of blood donors by using reverse transcriptase polymerase chain reaction (RT-PCR) analysis, and investigate HCV “window period” in blood donors.Methods Test blood donors for HCV-RNA by RT-PCR, and some positive cases were followed up. Results Among 28098 routine test negative blood donors, 77 (0.27%) were HCV-RNA positive. Eleven of the 77 HCV-RNA positive donors were followed up and 9 of them were later found to have increased ALT and/or positive anti-HCV. The interval between positive HCV-RNA test and abnormal serological tests was at least 4 weeks.Conclusion RT-PCR can identify HCV infected donors at an early stage. This test should become a routine test for blood donors to further ensure blood safety.